腺泡扩张Dilation Acinar · 凝固腺 · 雄性生殖系统 · NTP ntp-0440
诊断要点：如果对Figure 1所示程度的扩张作出腺泡扩张的诊断，则应对该变化进行分级，并在所有动物中一致地进行评估。
病变描述
腺泡扩张（acinar dilation）的特征是腺泡因大量分泌产物而膨胀，上皮乳头状皱襞减少或消失，被覆上皮变扁平。扩张的腺泡可通过其胀满的外观、潴留分泌物染色强度增加以及腺泡体积增大来识别。这很可能是与年龄相关的变化，与受试物给药之间的因果关系尚未确立。一些病理学家不对Figure 1所示程度的扩张作出诊断，认为其属于正常变异范围。Figure 2所示的腺泡扩张程度则明确需要诊断。
诊断与分级建议（NTP 共识）
如果对Figure 1所示程度的扩张作出腺泡扩张的诊断，则应对该变化进行分级，并在所有动物中一致地进行评估。在这种情况下，病理学描述可提供支持该诊断所用的诊断标准。Figure 2所示的扩张程度超出了预期的正常变异范围，应当作出诊断并进行分级。
图谱
英文原文
展开 NTP 官方英文描述与建议
Comment：
Acinar dilation is characterized by distension of glandular acini with abundant secretory product, reduction or loss of epithelial papillary folds, and flattening of the lining epithelium. Dilated acini may be distinguished by their turgid appearance, increased staining intensity of the retained secretion, and increased acinar size. This is likely an age-related change, and a causal association with chemical administration has not been established. Some pathologists do not diagnose the degree of dilation shown in Figure 1 and consider it to be within normal variation. The degree of ascinar dilation shown in Figure 2 definitely warrants diagnosis.
Recommendation：
If a diagnosis of acinar dilation is made for a degree of dilation as shown in Figure 1 , this change should be graded and consistently evaluated in all animals. In such a situation, the pathology narrative can provide diagnostic criteria used to support the diagnosis. The degree of dilation shown in Figure 2 is beyond expected normal variation and should be diagnosed and graded.
来源与引用
原始条目：https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-male/coagulating-gland/DilationAcinar
图谱总目录：NTP Nonneoplastic Lesion Atlas。 内容属美国联邦政府作品（公有领域），可引用；引用时请标注来源。
建议引用格式：NTP Nonneoplastic Lesion Atlas. Dilation Acinar (coagulating-gland). LabSmart 中文版：
https://www.labsmart.cn/ntp/coagulating-gland-dilation-acinar.html
中文图谱总页（可展开对照全部 595 条）：https://www.labsmart.cn/ntp-atlas.html#coagulating-gland-dilation-acinar