肌层变性Muscularis Degeneration · 食管 · 消化系统 · NTP ntp-0309
诊断要点:只要存在,肌层(tunica muscularis)的变性即应诊断为“食管,肌层 - 变性”,并根据病变范围进行分级。
病变描述
变性(degeneration)的特征是纤维体积减小(Figure 1、Figure 2)、过度收缩、“纤维扭曲卷曲”、细胞质呈均质嗜酸性至颗粒状或絮状、横纹消失以及矿化。巨噬细胞(macrophage)(Figure 3、Figure 4)常见于肌肉变性和坏死区域。灌胃创伤可导致食管肌壁损伤,引起肌肉变性和坏死或穿孔。
诊断与分级建议(NTP 共识)
只要存在,肌层(tunica muscularis)的变性即应诊断为“食管,肌层 - 变性”,并根据病变范围进行分级。病理学家认为该病变系化学暴露所致还是灌胃操作失误所致,应在文字描述中注明。
图谱


英文原文
展开 NTP 官方英文描述与建议
Comment:
Degeneration is characterized by decreased fiber size ( Figure 1 and Figure 2 ), hypercontraction, "twisting and curling of fibers," homogeneous eosinophilic to granular or floccular cytoplasm, loss of striations, and mineralization. Macrophages ( Figure 3 and Figure 4 ) are frequently found in areas of muscle degeneration and necrosis. Gavage trauma can result in damage to the muscular wall of the esophagus, resulting in muscle degeneration and necrosis or perforation.
Recommendation:
Whenever present, degeneration of the tunica muscularis should be diagnosed as "esophagus, muscularis - degeneration" and graded based upon the extent of the lesion. It should be noted in the narrative whether the pathologist considers this lesion to be due to chemical exposure or a gavage error.
来源与引用
原始条目:https://ntp.niehs.nih.gov/atlas/nnl/alimentary-system/esophagus/Muscularis-Degeneration
图谱总目录:NTP Nonneoplastic Lesion Atlas。 内容属美国联邦政府作品(公有领域),可引用;引用时请标注来源。
建议引用格式:NTP Nonneoplastic Lesion Atlas. Muscularis Degeneration (esophagus). LabSmart 中文版:
https://www.labsmart.cn/ntp/esophagus-muscularis-degeneration.html
中文图谱总页(可展开对照全部 595 条):https://www.labsmart.cn/ntp-atlas.html#esophagus-muscularis-degeneration