单核细胞性细胞浸润Infiltration Cellular Mononuclear Cell · 哈氏腺 · 特殊感觉系统 · NTP ntp-0313
诊断要点：哈德氏腺浸润应予以诊断并赋予严重程度分级，尤其是当发生率或严重程度出现与处理相关增加时。
病变描述
大鼠和小鼠哈德氏腺（Harderian gland）间质内小而局限的炎性细胞簇是常见的偶然性所见。这些浸润细胞最常见为单核细胞（淋巴细胞）（Figure 1、Figure 2），但也可能存在其他炎性细胞。此类浸润的发生率和严重程度增加也可与多种病理状态相关。细胞浸润与炎症的鉴别在于是否存在炎症的其他特征，如组织破坏、出血、纤维化、水肿或额外类型的白细胞。
诊断与分级建议（NTP 共识）
哈德氏腺浸润应予以诊断并赋予严重程度分级，尤其是当发生率或严重程度出现与处理相关增加时。诊断中应以修饰词标明所存在的主要细胞类型（例如，Harderian gland - Infiltration cellular, Mononuclear cell）。若细胞类型均匀混合（即无单一细胞类型占优势），可使用修饰词“mixed”。相关链接：Harderian Gland - Inflammation
图谱
英文原文
展开 NTP 官方英文描述与建议
Comment：
Small focal clusters of inflammatory cells in the interstitium are common incidental findings in the Harderian gland of rats and mice. These infiltrates are most commonly mononuclear cells (lymphocytes) ( Figure 1 and Figure 2 ), but other inflammatory cells may also be present. Increased incidences and severity of such infiltrates can also be associated with various pathologic conditions. Cellular infiltrates can be distinguished from inflammation by the presence of other features of inflammation, such as tissue destruction, hemorrhage, fibrosis, edema, or additional types of leukocytes.
Recommendation：
Harderian gland infiltrates should be diagnosed and assigned a severity grade, especially when there are treatment-related increases in incidence and/or severity. The predominant type of cell present should be indicated in the diagnosis as a modifier (e.g., Harderian gland - Infiltration cellular, Mononuclear cell). If there is an even mix of cell types (i.e., no one cell type predominates), the modifier "mixed" may be used. Related Links: Harderian Gland - Inflammation
来源与引用
图谱总目录：NTP Nonneoplastic Lesion Atlas。 内容属美国联邦政府作品（公有领域），可引用；引用时请标注来源。
建议引用格式：NTP Nonneoplastic Lesion Atlas. Infiltration Cellular Mononuclear Cell (harderian-gland). LabSmart 中文版：
https://www.labsmart.cn/ntp/harderian-gland-infiltration-cellular-mononuclear-cell.html
中文图谱总页（可展开对照全部 595 条）：https://www.labsmart.cn/ntp-atlas.html#harderian-gland-infiltration-cellular-mononuclear-cell