单核细胞性细胞浸润Infiltration Cellular Mononuclear Cell · 泪腺 · 特殊感觉系统 · NTP ntp-0321
诊断要点：只有当发生率和/或严重程度存在治疗相关差异时，才应对泪腺单核细胞浸润作出诊断并赋予严重程度分级。
病变描述
散在的、大小不一的单核细胞（通常为淋巴细胞）间质灶在大鼠和小鼠的泪腺中很常见（Figure 1、Figure 2），在老年动物中其发生率和严重程度往往增加。此类浸润的发生率和严重程度增加也可作为治疗相关的毒性效应或发生于其他病理状况中。
诊断与分级建议（NTP 共识）
只有当发生率和/或严重程度存在治疗相关差异时，才应对泪腺单核细胞浸润作出诊断并赋予严重程度分级。单核细胞浸润可通过炎症的特征与炎症相区分，如组织破坏、出血、纤维化、水肿以及其他白细胞类型的存在。相关链接：泪腺 - 炎症
图谱
英文原文
展开 NTP 官方英文描述与建议
Comment：
Scattered, variably sized interstitial foci of mononuclear cells (usually lymphocytes) are common in the lacrimal glands of rats and mice ( Figure 1 and Figure 2 ), often increasing in incidence and severity in older animals. Increased incidences and severity of such infiltrates can also occur as treatment-related toxic effects or in other pathologic conditions.
Recommendation：
Lacrimal gland mononuclear cell infiltrates should be diagnosed and assigned a severity grade only if there are treatment-related differences in the incidence and/or severity. Mononuclear cell infiltrates can be distinguished from inflammation by features of inflammation such as tissue destruction, hemorrhage, fibrosis, edema, and the presence of other leukocyte types. Related Links: Lacrimal Gland - Inflammation
来源与引用
图谱总目录：NTP Nonneoplastic Lesion Atlas。 内容属美国联邦政府作品（公有领域），可引用；引用时请标注来源。
建议引用格式：NTP Nonneoplastic Lesion Atlas. Infiltration Cellular Mononuclear Cell (lacrimal-gland). LabSmart 中文版：
https://www.labsmart.cn/ntp/lacrimal-gland-infiltration-cellular-mononuclear-cell.html
中文图谱总页（可展开对照全部 595 条）：https://www.labsmart.cn/ntp-atlas.html#lacrimal-gland-infiltration-cellular-mononuclear-cell