萎缩Atrophy · 淋巴结 · 免疫系统 · NTP ntp-0013
诊断要点：淋巴结萎缩应予以诊断并分级，除非确定其为年龄相关。评估淋巴结时还应考虑切面和部位。
病变描述
淋巴结萎缩（lymph node atrophy）可由任何引起淋巴细胞坏死或凋亡的毒性损伤或疾病所致。病变可包括副皮质区淋巴细胞耗竭（Figure 1，箭头）、滤泡数量和体积减少且生发中心极少至无（Figure 1，箭头head），以及髓索细胞密度降低；视严重程度而定，副皮质区基质细胞和高内皮微静脉可能更为显著（Figure 2，箭头）。淋巴细胞的进行性丢失可导致淋巴结缩小（萎缩），在大体或亚大体观察中可见。萎缩的淋巴组织可被脂肪组织及可能的胶原所取代。同一动物不同淋巴结之间的萎缩严重程度也可能存在差异。萎缩可由毒性损伤引起，但也可见于老龄大鼠和小鼠。年龄相关的变化不应诊断。
诊断与分级建议（NTP 共识）
淋巴结萎缩应予以诊断并分级，除非确定其为年龄相关。评估淋巴结时还应考虑切面和部位。
图谱
英文原文
展开 NTP 官方英文描述与建议
Comment：
Lymph node atrophy may result from any toxic insult or disease that causes lymphocyte necrosis or apoptosis. Changes may include depletion of paracortical lymphocytes ( Figure 1 , arrow), a decrease in the number and size of follicles with few to no germinal centers ( Figure 1 , arrowhead), and a decrease in cellularity of medullary cords; depending on severity, the paracortical stromal cells and high endothelial venules may be more prominent ( Figure 2 , arrows). Progressive loss of lymphocytes may cause shrinking (atrophy) of a lymph node that is apparent grossly or subgrossly. Atrophic lymphoid tissue may be replaced by adipose tissue and possibly collagen. The severity of atrophy may also vary between lymph nodes within the same animal. Atrophy may result from toxic insult but may also be seen in aged rats and mice. Age-related changes should not be diagnosed.
Recommendation：
Lymph node atrophy should be diagnosed and graded unless it is determined to be age related. Plane of section and location should also be considered when evaluating the lymph nodes.
来源与引用
原始条目：https://ntp.niehs.nih.gov/atlas/nnl/immune-system/lymph-node/Atrophy
图谱总目录：NTP Nonneoplastic Lesion Atlas。 内容属美国联邦政府作品（公有领域），可引用；引用时请标注来源。
建议引用格式：NTP Nonneoplastic Lesion Atlas. Atrophy (lymph-node). LabSmart 中文版：
https://www.labsmart.cn/ntp/lymph-node-atrophy.html
中文图谱总页（可展开对照全部 595 条）：https://www.labsmart.cn/ntp-atlas.html#lymph-node-atrophy