异物Foreign Body · 口腔黏膜 · 消化系统 · NTP ntp-0222
诊断要点:异物应当诊断,但不进行分级。如果存在炎症且炎症是病变的重要组成部分,则应单独诊断并分级,分级依据炎性细胞浸润的密度和范围。
病变描述
异物最常见的是来自垫料或饲料的植物性物质(Figure 1、Figure 2、Figure 3、Figure 4)或毛干(Figure 5、Figure 6、Figure 7、Figure 8)。异物可以是原发性的或继发性的。伴有溃疡形成的炎症可由创伤、感染或毒性化学物质引起,并可导致异物继发性地穿入口腔较深的组织。根据存在的异物类型和持续时间,异物周围可见任何类型的炎症,但化脓性炎症最为常见。日粮类型及其稠度可影响所观察到的口腔病变的发生频率和类型。饲喂含食物纤维的粉状日粮后,可发生牙周炎和瘘管。受累牙齿周围可出现伴有纤维化的局部肉芽肿性炎症。牙周沟处可形成牙周袋,且常是异物和炎性渗出物通过的途径。口腔、咽和鼻上皮内异物引起的慢性刺激和炎症可导致鳞状细胞癌的形成。
诊断与分级建议(NTP 共识)
异物应当诊断,但不进行分级。如果存在炎症且炎症是病变的重要组成部分,则应单独诊断并分级,分级依据炎性细胞浸润的密度和范围。如果异物局限于牙周袋内且未穿入组织,则不诊断异物,该病变记录为“牙齿-牙周袋”(参见相应文件)。
图谱


英文原文
展开 NTP 官方英文描述与建议
Comment:
Foreign bodies are most frequently plant material from the bedding or feed ( Figure 1 , Figure 2 , Figure 3 , and Figure 4 ) or hair shafts ( Figure 5 , Figure 6 , Figure 7 , and Figure 8 ). Foreign bodies can be primary or secondary. Inflammation with ulceration can result from trauma, infection, or toxic chemicals and can result in foreign material secondarily penetrating the deeper tissues of the oral cavity. Depending on the type of foreign material present and the duration, any type of inflammation can be seen around a foreign body, but suppurative inflammation is the most common. The type of diet and its consistency can influence the frequency and types of oral cavity lesions observed. Periodontitis and fistulas can occur following the feeding of powdered diets that contain food fibers. Localized granulomatous inflammation with fibrosis can be present around the affected tooth. A periodontal pocket may form at the dental sulcus and is often the route of passage for foreign material and inflammatory exudates. Chronic irritation and inflammation induced by foreign bodies in the epithelium of the mouth, pharynx, and nose can lead to formation of squamous cell carcinoma.
Recommendation:
A foreign body should be diagnosed but not graded. If inflammation is present and is a significant component of the lesion, it should be diagnosed and graded separately, with the grading based on the density and extent of inflammatory cell infiltration. If foreign material is confined to a periodontal pocket and has not penetrated into the tissue, then foreign body is not diagnosed and the lesion is recorded as "tooth - periodontal pocket" (see appropriate document).
来源与引用
原始条目:https://ntp.niehs.nih.gov/atlas/nnl/alimentary-system/oral-mucosa/ForeignBody
图谱总目录:NTP Nonneoplastic Lesion Atlas。 内容属美国联邦政府作品(公有领域),可引用;引用时请标注来源。
建议引用格式:NTP Nonneoplastic Lesion Atlas. Foreign Body (oral-mucosa). LabSmart 中文版:
https://www.labsmart.cn/ntp/oral-mucosa-foreign-body.html
中文图谱总页(可展开对照全部 595 条):https://www.labsmart.cn/ntp-atlas.html#oral-mucosa-foreign-body