牙龈异位组织Gingiva Ectopic Tissue · 口腔黏膜 · 消化系统 · NTP ntp-0225
诊断要点：该发现应诊断为“口腔黏膜，牙龈 - 异位组织，皮脂腺”。无需分级。
病变描述
口腔内的异位皮脂腺（ectopic sebaceous glands）也称为福代斯颗粒（Fordyce’s granules）。组织学上，这些是未与毛囊相关的皮脂腺集合（Figure 1、Figure 2、Figure 3、Figure 4）。磨牙牙龈中的腺体常伴有充满皮脂的囊性扩张导管。在一项检查734只雄性 and 722只雌性F344大鼠的NTP研究中，福代斯颗粒在雄性上切牙正中矢状牙龈中非常常见，且发生率随年龄增长而增加（26周、65周和2年研究中分别为34.2%、50%和56.3%）。异位皮脂腺在雌性中罕见（26周、65周和2年研究中分别为0%、0%和2.8%）。磨牙牙龈的异位皮脂腺在雌雄两性中均非常罕见。异位皮脂腺在大体检查中常不明显，被视为偶然发现。
诊断与分级建议（NTP 共识）
该发现应诊断为“口腔黏膜，牙龈 - 异位组织，皮脂腺”。无需分级。
图谱
英文原文
展开 NTP 官方英文描述与建议
Comment：
Ectopic sebaceous glands in the oral cavity are also known as Fordyce’s granules. Histologically, these are a collection of sebaceous glands unassociated with hair follicles ( Figure 1 , Figure 2 , Figure 3 , and Figure 4 ). The glands in the molar gingiva are often associated with cystically dilated ducts filled with sebum. In one NTP study examining 734 male and 722 female F344 rats, Fordyce’s granules were very common in the midsagittal gingiva of the upper incisor in males and increased in incidence with age (34.2%, 50%, and 56.3% in 26-week, 65-week, and 2-year studies, respectively). Ectopic sebaceous glands were rare in females (0%, 0%, and 2.8% in 26-week, 65-week, and 2-year studies, respectively). Ectopic sebaceous glands of the molar gingiva were very rare in both sexes. Ectopic sebaceous glands are often not noticeable on gross examination and are considered an incidental finding.
Recommendation：
This finding should be diagnosed as "Oral mucosa, gingiva - ectopic tissue, sebaceous gland." No grade is necessary.
来源与引用
原始条目：https://ntp.niehs.nih.gov/atlas/nnl/alimentary-system/oral-mucosa/Gingiva-EctopicTissue
图谱总目录：NTP Nonneoplastic Lesion Atlas。 内容属美国联邦政府作品（公有领域），可引用；引用时请标注来源。
建议引用格式：NTP Nonneoplastic Lesion Atlas. Gingiva Ectopic Tissue (oral-mucosa). LabSmart 中文版：
https://www.labsmart.cn/ntp/oral-mucosa-gingiva-ectopic-tissue.html
中文图谱总页（可展开对照全部 595 条）：https://www.labsmart.cn/ntp-atlas.html#oral-mucosa-gingiva-ectopic-tissue