脂肪变性Fatty Change · 卵巢 · 雌性生殖系统 · NTP ntp-0519
诊断要点：卵巢——脂肪变化只要存在就应诊断并分级。
病变描述
卵巢——脂肪变化（fatty change）的特征是一簇边界清楚、部分有包膜、轻度压迫周围组织的细胞，其形态为典型的脂肪细胞（adipocyte）（Figure 1、Figure 2）。多边形细胞的胞质内存在大小不一的大的透明空泡，将扁平的细胞核挤向细胞边缘。间质细胞（interstitial cell）、膜细胞（thecal cell）和颗粒细胞（granulosa cell）含有大量脂滴。脂肪变化可由抑制类固醇激素合成的药物诱发，导致脂质在卵巢间质中蓄积。用咪唑类抗真菌药处理的大鼠卵巢间质细胞中脂质增加，同时还伴有脂褐素（lipofuscin）沉积。
诊断与分级建议（NTP 共识）
卵巢——脂肪变化只要存在就应诊断并分级。
图谱
英文原文
展开 NTP 官方英文描述与建议
Comment：
Ovary - Fatty change is characterized by a well-circumscribed, partially encapsulated, slightly compressing cluster of cells with the appearance typical of adipocytes ( Figure 1 and Figure 2 ). Large, variably sized, clear vacuoles are present in the cytoplasm of polygonal cells, displacing the flattened nucleus to the periphery of the cell. Interstitial, thecal, and granulosa cells contain numerous lipid droplets. Fatty change may be induced by drugs inhibiting steroid hormone synthesis, resulting in lipid accumulation in the ovarian stroma. Rats treated with an imidazole antifungal drug had increased lipid in the interstitial cells of the ovary, which was also associated with deposition of lipofuscin.
Recommendation：
Ovary - Fatty change should be diagnosed and graded whenever present.
来源与引用
原始条目：https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-female/ovary/FattyChange
图谱总目录：NTP Nonneoplastic Lesion Atlas。 内容属美国联邦政府作品（公有领域），可引用；引用时请标注来源。
建议引用格式：NTP Nonneoplastic Lesion Atlas. Fatty Change (ovary). LabSmart 中文版：
https://www.labsmart.cn/ntp/ovary-fatty-change.html
中文图谱总页（可展开对照全部 595 条）：https://www.labsmart.cn/ntp-atlas.html#ovary-fatty-change