纤维化Fibrosis · 睾丸 · 雄性生殖系统 · NTP ntp-0474
诊断要点：如果纤维化代表原发病变，且其范围和严重程度足以构成诊断依据，则应予以诊断并分级；
病变描述
虽然睾丸慢性炎症中可见少量纤维化，但Figure 1中所见的纤维化程度足以构成独立诊断。纤维化通常与坏死和炎症后成纤维细胞和胶原替代睾丸实质有关。这可以是局灶性（focal）、多灶性（multifocal）或广泛的（Figure 1，星号），并可延伸至白膜。纤维化可能伴有矿化（箭头）和炎症（Figure 2）。分布可以是单侧或双侧。大鼠中，慢性可卡因或镉给药可诱导睾丸纤维化。
诊断与分级建议（NTP 共识）
如果纤维化代表原发病变，且其范围和严重程度足以构成诊断依据，则应予以诊断并分级；如果其发生率和/或严重程度似乎与化学物给药相关，则应在病理学叙述中加以讨论。如果双侧睾丸均存在，则应诊断为双侧性。
图谱
英文原文
展开 NTP 官方英文描述与建议
Comment：
While modest amounts of fibrosis can be seen in chronic inflammation of the testis, the degree of fibrosis present in Figure 1 warrants an independent diagnosis. Fibrosis is usually associated with replacement of testicular parenchyma by fibroblasts and collagen following necrosis and inflammation. This can be focal, multifocal, or extensive (Figure 1, asterisk), with extension to the tunica albuginea. The fibrosis may be accompanied by mineralization (arrow) and inflammation ( Figure 2 ). Distribution can be unilateral or bilateral. Testicular fibrosis is induced in rats by chronic cocaine or cadmium administration.
Recommendation：
Fibrosis should be diagnosed and graded if it represents a primary lesion and when warranted by extent and severity and should be discussed in the pathology narrative if the incidence and/or severity appears to be related to chemical administration. If present in both testes, it should be diagnosed as bilateral.
来源与引用
原始条目：https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-male/testis/Fibrosis
图谱总目录：NTP Nonneoplastic Lesion Atlas。 内容属美国联邦政府作品（公有领域），可引用；引用时请标注来源。
建议引用格式：NTP Nonneoplastic Lesion Atlas. Fibrosis (testis). LabSmart 中文版：
https://www.labsmart.cn/ntp/testis-fibrosis.html
中文图谱总页（可展开对照全部 595 条）：https://www.labsmart.cn/ntp-atlas.html#testis-fibrosis