矿化Mineralization · 睾丸 · 雄性生殖系统 · NTP ntp-0470

依据美国国家毒理学计划(NTP)Nonneoplastic Lesion Atlas 整理 · 中文译文与诊断建议 · 仅供科研使用,不用于临床诊断

一句话结论:营养不良性矿化(dystrophic mineralization)是损伤的后遗症,可累及被膜(Figure 1)、血管(Figure 3)或生精小管(Figure 2、Figure 4)。
诊断要点:矿化应通过恰当使用部位修饰词(如血管、被膜、生精小管)就其位置进行诊断、分级和分类。

病变描述

营养不良性矿化(dystrophic mineralization)是损伤的后遗症,可累及被膜(Figure 1)、血管(Figure 3)或生精小管(Figure 2、Figure 4)。其特征为嗜碱性、细至粗颗粒状至无定形、层状物质蓄积,伴或不伴组织结构扭曲。它常是生精小管内精子淤滞的后遗症。矿化是一种年龄相关所见,可为单侧或双侧。

诊断与分级建议(NTP 共识)

矿化应通过恰当使用部位修饰词(如血管、被膜、生精小管)就其位置进行诊断、分级和分类。若双侧睾丸均存在,应诊断为双侧。相关病变,如变性、坏死或炎症,若严重程度需要,应单独诊断。

图谱

矿化(睾丸)组织学图谱 1
图 1 · 矿化 · 来源:NTP NNL Atlas
矿化(睾丸)组织学图谱 2
图 2 · 矿化 · 来源:NTP NNL Atlas

英文原文

展开 NTP 官方英文描述与建议

Comment:
Dystrophic mineralization is a sequel of injury and may involve the capsule ( Figure 1 ), blood vessels ( Figure 3 ), or seminiferous tubules ( Figure 2 and Figure 4 ). It is characterized by accumulation of basophilic, fine to coarsely granular to amorphous, laminated material, with or without distortion of the tissue architecture. It is often a sequel to sperm stasis within the seminiferous tubules. Mineralization is an age-related finding and can be seen unilaterally or bilaterally.

Recommendation:
Mineralization should be diagnosed, graded, and classified with respect to location through appropriate use of site modifiers (e.g., blood vessel, capsule, seminiferous tubule). If present in both testes, it should be diagnosed as bilateral. Associated lesions, such as degeneration, necrosis, or inflammation should be diagnosed separately if warranted by severity. Pagination Figure 1 of 4 Next page › Testis - Mineralization in a male B6C3F1 mouse from a chronic study. Mineralization involving the testicular capsule. Enlarge Image All Images Enlarge All Images Testis - Mineralization in a male B6C3F1 mouse from a chronic study. Mineralization involving the testicular capsule. "> Testis - Mineralization in a male B6C3F1 mouse from a chronic study. Mineralization involving the testicular capsule. " /> Testis - Mineralization in a male B6C3F1 mouse from a chronic study. Mineralization involving the testicular capsule. Testis - Mineralization in a male B6C3F1 mouse from a subchronic study. Mineralization involving seminiferous tubules. "> Testis - Mineralization in a male B6C3F1 mouse from a subchronic study. Mineralization involving seminiferous tubules. " /> Testis - Mineralization in a male B6C3F1 mouse from a subchronic study. Mineralization involving seminiferous tubules. Testis - Mineralization in a male F344/N rat from a chronic study. Mineralization involving blood vessels. "> Testis - Mineralization in a male F344/N rat from a chronic study. Mineralization involving blood vessels. " /> Testis - Mineralization in a male F344/N rat from a chronic study. Mineralization involving blood vessels. Testis - Mineralization in a male B6C3F1 mouse from a chronic study. Mineralized seminiferous tubules. "> Testis - Mineralization in a male B6C3F1 mouse from a chronic study. Mineralized seminiferous tubules. " /> Testis - Mineralization in a male B6C3F1 mouse from a chronic study. Mineralized seminiferous tubules.

来源与引用

原始条目:https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-male/testis/Mineralization

图谱总目录:NTP Nonneoplastic Lesion Atlas。 内容属美国联邦政府作品(公有领域),可引用;引用时请标注来源。

建议引用格式:NTP Nonneoplastic Lesion Atlas. Mineralization (testis). LabSmart 中文版: https://www.labsmart.cn/ntp/testis-mineralization.html

中文图谱总页(可展开对照全部 595 条):https://www.labsmart.cn/ntp-atlas.html#testis-mineralization

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