精子停滞Sperm Stasis · 睾丸 · 雄性生殖系统 · NTP ntp-0471

依据美国国家毒理学计划(NTP)Nonneoplastic Lesion Atlas 整理 · 中文译文与诊断建议 · 仅供科研使用,不用于临床诊断

一句话结论:精子停滞(sperm stasis)是由于精子在生精小管或睾丸网管内嵌塞所致。通常见于萎缩的小管内,嵌塞的精子常发生矿化(Figure 2,箭头)。
诊断要点:除非精子停滞是独立于生殖细胞变性或生精上皮萎缩而发生的显著发现,否则不应记录或记载。

病变描述

精子停滞(sperm stasis)是由于精子在生精小管或睾丸网管内嵌塞所致。通常见于萎缩的小管内,嵌塞的精子常发生矿化(Figure 2,箭头)。精子停滞与精子囊肿(spermatocele)的鉴别在于小管尺寸较小(精子停滞时小管直径小于正常小管或管道直径的两倍),与精子肉芽肿(sperm granuloma)的鉴别在于无炎症反应。受累小管常位于睾丸网附近。精子停滞是一种常见的年龄相关偶然性发现,伴随小管变性和萎缩。

诊断与分级建议(NTP 共识)

除非精子停滞是独立于生殖细胞变性或生精上皮萎缩而发生的显著发现,否则不应记录或记载。当确需作出诊断时,应给予严重程度分级,并在存在双侧性时将其纳入诊断。

图谱

精子停滞(睾丸)组织学图谱 1
图 1 · 精子停滞 · 来源:NTP NNL Atlas
精子停滞(睾丸)组织学图谱 2
图 2 · 精子停滞 · 来源:NTP NNL Atlas

英文原文

展开 NTP 官方英文描述与建议

Comment:
Sperm stasis results from impaction of spermatozoa in a seminiferous tubule or rete testis duct. It is generally seen within an atrophic tubule, and the impacted sperm often become mineralized ( Figure 2 , arrows). Sperm stasis is distinguished from a spermatocele by the smaller size of the tubule (in sperm stasis the tubule is less than twice the diameter of a normal tubule or duct) and from a sperm granuloma by the absence of an inflammatory response. Affected tubules are often located close to the rete. Sperm stasis is a common age-associated incidental finding that accompanies tubular degeneration and atrophy.

Recommendation:
Sperm stasis should not be recorded or documented unless it is a prominent finding that occurs independent of germ cell degeneration or germinal epithelial atrophy. When a diagnosis is warranted, it should be given a severity grade, and bilaterality should be included in the diagnosis when present. Pagination Figure 1 of 2 Next page › Testis - Sperm stasis in a male B6C3F1 mouse from a chronic study. Sperm stasis in a testicular tubule. Enlarge Image All Images Enlarge All Images Testis - Sperm stasis in a male B6C3F1 mouse from a chronic study. Sperm stasis in a testicular tubule. "> Testis - Sperm stasis in a male B6C3F1 mouse from a chronic study. Sperm stasis in a testicular tubule. " /> Testis - Sperm stasis in a male B6C3F1 mouse from a chronic study. Sperm stasis in a testicular tubule. Testis - Sperm stasis in a male F344/N rat from a chronic study. Arrows indicate focal mineralization of sperm. "> Testis - Sperm stasis in a male F344/N rat from a chronic study. Arrows indicate focal mineralization of sperm. " /> Testis - Sperm stasis in a male F344/N rat from a chronic study. Arrows indicate focal mineralization of sperm.

来源与引用

原始条目:https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-male/testis/SpermStasis

图谱总目录:NTP Nonneoplastic Lesion Atlas。 内容属美国联邦政府作品(公有领域),可引用;引用时请标注来源。

建议引用格式:NTP Nonneoplastic Lesion Atlas. Sperm Stasis (testis). LabSmart 中文版: https://www.labsmart.cn/ntp/testis-sperm-stasis.html

中文图谱总页(可展开对照全部 595 条):https://www.labsmart.cn/ntp-atlas.html#testis-sperm-stasis

淀粉样物质炎症生殖细胞脱落生精上皮变性生精上皮萎缩生精小管坏死