纤维性骨营养不良Fibrous Osteodystrophy · 骨 · 骨骼肌肉系统 · NTP ntp-0577
诊断要点：已显示若干 NTP 化合物可因大鼠的慢性进行性肾病而诱导甲状旁腺增生，因此，FOD 可能是化合物诱导的病变。
病变描述
纤维性骨营养不良（fibrous osteodystrophy，FOD）（Figure 1、Figure 2、Figure 3）（以前称为骨发育不良、纤维性结构不良和骨纤维化）的特征是松质骨或皮质骨的破骨细胞性吸收，并被疏松至成熟的纤维结缔组织所取代。该病变是一种代谢性骨病的结果，与甲状旁腺功能亢进同时发生，无论是由功能性甲状旁腺肿瘤（原发性）还是慢性肾脏疾病（继发性）所致。原发性主细胞瘤在啮齿类动物中非常罕见且通常无功能，最常见的是，FOD 作为继发性甲状旁腺功能亢进伴随慢性进行性肾病的后果而发生。慢性进行性肾病可因各种化学物的处理而加重，导致继发性甲状旁腺功能亢进、FOD 以及包括心脏、主动脉和其他软组织在内的多种器官的转移性钙化。早期 FOD 病变的特征是受累骨呈虫蚀状外观，破骨细胞数量增加以及成熟骨的“扇贝样”改变（Figure 3），最终进展为被纤维结缔组织和未成熟类骨质所取代（Figure 1、Figure 2）。FOD 在 B6C3F1 小鼠中的发生率较低（雌性 1%，雄性 0%），这是由于该品系慢性肾衰竭的发生率较低。
诊断与分级建议（NTP 共识）
已显示若干 NTP 化合物可因大鼠的慢性进行性肾病而诱导甲状旁腺增生，因此，FOD 可能是化合物诱导的病变。因此，尽管它可以是患有慢性进行性肾病的老年大鼠的背景病变，但在发生率或严重程度呈剂量相关增加的研究中，FOD 应被报告并给予严重程度分级。该病变应诊断为 FOD，而不是分别诊断该病变的各个组成部分（例如，骨减少、纤维化）。相关链接：骨 - 纤维骨性病变
图谱
英文原文
展开 NTP 官方英文描述与建议
Comment：
Fibrous osteodystrophy (FOD) ( Figure 1 , Figure 2 , and Figure 3 ) (previously referred to as osteodysplasia, fibrous dysplasia, and osteofibrosis) is characterized by osteoclastic resorption of cancellous or cortical bone, with replacement by loose to mature fibrous connective tissue. This lesion is the result of a metabolic bone disease that occurs in conjunction with hyperparathyroidism, whether due to a functional parathyroid tumor (primary) or chronic renal disease (secondary). Primary chief cell tumors are very uncommon and usually nonfunctional in rodents, and most often, FOD occurs as a result of secondary hyperparathyroidism in conjunction with chronic progressive nephropathy. Exacerbation of chronic progressive nephropathy may result from treatment by various chemicals, leading to secondary hyperparathyroidism, FOD, and metastatic calcification of various organs, including the heart, aorta, and other soft tissues. Early FOD lesions are characterized by a moth-eaten appearance of the affected bone, with increased osteoclast numbers and "scalloping" of mature bone ( Figure 3 ), eventually progressing to replacement by fibrous connective tissue and immature osteoid ( Figure 1 and Figure 2 ). The incidence of FOD is low in B6C3F1 mice (1% in females, 0% in males) due to the low incidence of chronic renal failure in this strain.
Recommendation：
Several NTP compounds have been shown to induce parathyroid hyperplasia as a result of chronic progressive nephropathy in rats, and as such, FOD may be a compound-induced lesion. Therefore, although it can be a background lesion in aged rats with chronic progressive nephropathy, FOD should be reported and given a severity grade in studies in which there is a dose-related increase in incidence or severity. This lesion should be diagnosed as FOD rather than diagnosing the components of the lesion separately (e.g., decreased bone, fibrosis). Related Links: Bone - Fibro-osseous Lesion
来源与引用
原始条目：https://ntp.niehs.nih.gov/atlas/nnl/musculoskeletal-system/bone/FibrousOsteodystrophy
图谱总目录：NTP Nonneoplastic Lesion Atlas。 内容属美国联邦政府作品（公有领域），可引用；引用时请标注来源。
建议引用格式：NTP Nonneoplastic Lesion Atlas. Fibrous Osteodystrophy (bone). LabSmart 中文版：
https://www.labsmart.cn/ntp/bone-fibrous-osteodystrophy.html
中文图谱总页（可展开对照全部 595 条）：https://www.labsmart.cn/ntp-atlas.html#bone-fibrous-osteodystrophy