淀粉样物质Amyloid · 附睾 · 雄性生殖系统 · NTP ntp-0499
诊断要点:淀粉样物质应记录并分级,如果其发生率和/或严重程度似乎与化学物给药相关,则应在病理学叙述中讨论。
病变描述
淀粉样变性(amyloidosis)是一种与年龄相关的偶然性背景病变,最常见于小鼠。它通常是一种全身性病变,但附睾是常见的沉积部位。其表现为淡染、嗜酸性细胞外物质,刚果红(Congo red)染色后在偏振光下呈绿色双折射。
诊断与分级建议(NTP 共识)
淀粉样物质应记录并分级,如果其发生率和/或严重程度似乎与化学物给药相关,则应在病理学叙述中讨论。相关或继发性病变除非其严重程度足以需要诊断,否则不必诊断。
图谱


英文原文
展开 NTP 官方英文描述与建议
Comment:
Amyloidosis is an age-related, incidental background finding most commonly seen in mice. It is generally a systemic condition, but the epididymis is a common site for deposition. It appears as pale, eosinophilic extracellular material that has a green birefringence under polarized light when stained with Congo red.
Recommendation:
Amyloid should be recorded and graded and should be discussed in the pathology narrative if the incidence and/or severity appear to be related to chemical administration. Associated or secondary lesions need not be diagnosed unless warranted by their severity.
来源与引用
原始条目:https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-male/epididymis/Amyloid
图谱总目录:NTP Nonneoplastic Lesion Atlas。 内容属美国联邦政府作品(公有领域),可引用;引用时请标注来源。
建议引用格式:NTP Nonneoplastic Lesion Atlas. Amyloid (epididymis). LabSmart 中文版:
https://www.labsmart.cn/ntp/epididymis-amyloid.html
中文图谱总页(可展开对照全部 595 条):https://www.labsmart.cn/ntp-atlas.html#epididymis-amyloid