巩膜骨性化生Sclera Metaplasia Osseous · 眼 · 特殊感觉系统 · NTP ntp-0328
诊断要点:巩膜骨性化生只有在与处理相关时才应诊断,但不需要严重程度分级(即应记录为“存在”)。
病变描述
巩膜骨性化生(osseous metaplasia)是一种随年龄增长而发生的偶然性改变,在Fischer 344/N大鼠中频繁发生,在其他常见大鼠品系中较少发生,而在小鼠中即使有也极为罕见。其表现为单个至多个、离散的、分化良好的矿化骨灶。偶尔可观察到类似的巩膜软骨灶(软骨性化生,cartilaginous metaplasia)。这些无害的结构不会引起巩膜或邻近组织的病理学改变。
诊断与分级建议(NTP 共识)
巩膜骨性化生只有在与处理相关时才应诊断,但不需要严重程度分级(即应记录为“存在”)。
图谱


英文原文
展开 NTP 官方英文描述与建议
Comment:
Osseous metaplasia of the sclera is an incidental aging change that occurs frequently in Fischer 344/N rats, less often in other common rat strains, and seldom if ever in mice. It consists of single to multiple, discrete foci of well-differentiated, mineralized bone. Occasionally, similar scleral foci of cartilage are observed (cartilaginous metaplasia). These innocuous structures do not incite pathologic changes in the sclera or adjacent tissues.
Recommendation:
Scleral osseous metaplasia should be diagnosed only if treatment related, but it does not need a severity grade (i.e., it should be recorded as "present").
来源与引用
原始条目:https://ntp.niehs.nih.gov/atlas/nnl/special-senses-system/eye/Sclera-MetaplasiaOsseous
图谱总目录:NTP Nonneoplastic Lesion Atlas。 内容属美国联邦政府作品(公有领域),可引用;引用时请标注来源。
建议引用格式:NTP Nonneoplastic Lesion Atlas. Sclera Metaplasia Osseous (eye). LabSmart 中文版:
https://www.labsmart.cn/ntp/eye-sclera-metaplasia-osseous.html
中文图谱总页(可展开对照全部 595 条):https://www.labsmart.cn/ntp-atlas.html#eye-sclera-metaplasia-osseous