萎缩Atrophy · 哈氏腺 · 特殊感觉系统 · NTP ntp-0320
诊断要点：哈德氏腺萎缩只要存在即应诊断并赋予严重程度分级。任何相关的反应性纤维化除非严重程度确有必要，否则不应单独诊断，但应在病理描述中予以描述。
病变描述
哈德氏腺（Harderian gland）萎缩（伴或不伴纤维化）可由多种原因引起，包括眼球后出血操作所致创伤；基因突变；营养缺乏；对异物或过量卟啉分泌物质积聚的反应；或各种原因所致变性或炎症的继发结果。该病变的特征为腺泡皱缩至轻度扩张、迂曲，衬覆不同程度变扁平的上皮细胞（Figure 1、Figure 2）。萎缩常伴有间质纤维化。
诊断与分级建议（NTP 共识）
哈德氏腺萎缩只要存在即应诊断并赋予严重程度分级。任何相关的反应性纤维化除非严重程度确有必要，否则不应单独诊断，但应在病理描述中予以描述。其他相关病变（如炎症）应单独诊断。如果萎缩是另一病变（如炎症或纤维化）的主要组成部分，则无需单独诊断（除非严重程度确有必要），但应在病理描述中予以描述。
图谱
英文原文
展开 NTP 官方英文描述与建议
Comment：
Harderian gland atrophy (with or without concurrent fibrosis) results from various causes, including trauma from retro-bulbar bleeding procedures; genetic mutations; nutritional deficiencies; as a reaction to foreign bodies or accretions of excess porphyrin secretory material; or as a sequel to degeneration or inflammation from various causes. The lesion is characterized by alveoli that are shrunken to slightly widened, tortuous, and lined by variably flattened epithelial cells ( Figure 1 and Figure 2 ). Atrophy is often accompanied by interstitial fibrosis.
Recommendation：
Harderian gland atrophy should be diagnosed and assigned a severity grade whenever present. Any associated reactive fibrosis should not be diagnosed separately unless warranted by severity, but should be described in the pathology narrative. Other associated lesions (such as inflammation) should be diagnosed separately. If atrophy is a main component of another lesion (such as inflammation or fibrosis), it need not be diagnosed separately (unless warranted by severity), but should be described in the pathology narrative.
来源与引用
原始条目：https://ntp.niehs.nih.gov/atlas/nnl/special-senses-system/harderian-gland/Atrophy
图谱总目录：NTP Nonneoplastic Lesion Atlas。 内容属美国联邦政府作品（公有领域），可引用；引用时请标注来源。
建议引用格式：NTP Nonneoplastic Lesion Atlas. Atrophy (harderian-gland). LabSmart 中文版：
https://www.labsmart.cn/ntp/harderian-gland-atrophy.html
中文图谱总页（可展开对照全部 595 条）：https://www.labsmart.cn/ntp-atlas.html#harderian-gland-atrophy