间质细胞浸润Interstitium Infiltration Cellular · 肾脏 · 泌尿系统 · NTP ntp-0183

依据美国国家毒理学计划(NTP)Nonneoplastic Lesion Atlas 整理 · 中文译文与诊断建议 · 仅供科研使用,不用于临床诊断

一句话结论:在啮齿类动物的肾脏中,细胞浸润(cellular infiltration)是常规观察到的现象(Figure 1)。
诊断要点:当细胞浸润与处理相关时,应予以诊断。若与处理无关,其诊断由病理学家自行决定。若予以诊断,应在诊断中以修饰词的形式标明细胞类型(例如,肾脏,间质 - 浸润,细胞性,淋巴细胞)。

病变描述

在啮齿类动物的肾脏中,细胞浸润(cellular infiltration)是常规观察到的现象(Figure 1)。浸润细胞通常为淋巴样细胞或单核细胞,但其他炎症细胞类型也可能构成浸润。这些浸润一般随年龄增长而增加。在许多情况下,它们属于背景性发现,病理学意义很小。必须将细胞浸润与炎症(inflammation)相鉴别。一般而言,当炎症细胞数量相对较少且不伴有其他炎症指征(如水肿、出血、组织损伤)时,诊断为细胞浸润。

诊断与分级建议(NTP 共识)

当细胞浸润与处理相关时,应予以诊断。若与处理无关,其诊断由病理学家自行决定。若予以诊断,应在诊断中以修饰词的形式标明细胞类型(例如,肾脏,间质 - 浸润,细胞性,淋巴细胞)。相关链接:肾脏 - 炎症

图谱

间质细胞浸润(肾脏)组织学图谱 1
图 1 · 间质细胞浸润 · 来源:NTP NNL Atlas

英文原文

展开 NTP 官方英文描述与建议

Comment:
Cellular infiltrates are routinely observed in the kidneys of rodents ( Figure 1 ). The infiltrating cells are typically lymphoid or mononuclear cells, but other inflammatory cell types may comprise the infiltrates. These infiltrates generally increase with age. In many cases, they represent a background finding that has little pathologic significance. Cellular infiltration must be differentiated from inflammation. In general, cellular infiltration is diagnosed when the number of inflammatory cells is relatively low and no other indicators of inflammation (e.g., edema, hemorrhage, tissue damage) accompany the cells.

Recommendation:
Cellular infiltration should be diagnosed when it is treatment related. If it is not treatment related, its diagnosis is left to the discretion of the pathologist. If diagnosed, the cell type should be indicated in the diagnosis as a modifier (e.g., Kidney, Interstitium - Infiltration, Cellular, Lymphocyte). Related Links: Kidney - Inflammation

来源与引用

原始条目:https://ntp.niehs.nih.gov/atlas/nnl/urinary-system/kidney/Interstitium-InfiltrationCellular

图谱总目录:NTP Nonneoplastic Lesion Atlas。 内容属美国联邦政府作品(公有领域),可引用;引用时请标注来源。

建议引用格式:NTP Nonneoplastic Lesion Atlas. Interstitium Infiltration Cellular (kidney). LabSmart 中文版: https://www.labsmart.cn/ntp/kidney-interstitium-infiltration-cellular.html

中文图谱总页(可展开对照全部 595 条):https://www.labsmart.cn/ntp-atlas.html#kidney-interstitium-infiltration-cellular

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