肾小管管型Renal Tubule Cast · 肾脏 · 泌尿系统 · NTP ntp-0174
诊断要点：肾小管管型应根据其形态学表现（颗粒性、透明性等）作出诊断，并给出严重程度分级。作为慢性进行性肾病组成部分观察到的透明管型不应单独诊断。
病变描述
管型（intratubular casts）可具有多种成分，并呈现不同的形态学和染色特征。透明管型（hyaline casts）和颗粒管型（granular casts）均可在多种肾脏疾病中观察到。常见的管型包括：与肾小球通透性增高（如慢性进行性肾病）相关的透明管型（嗜酸性、均质性蛋白性物质）（Figure 1），以及提示既往肾小管细胞坏死的颗粒管型（坏死细胞碎片），后者与诱导α2u-球蛋白肾病的化学物相关（Figure 2、Figure 3）。
诊断与分级建议（NTP 共识）
肾小管管型应根据其形态学表现（颗粒性、透明性等）作出诊断，并给出严重程度分级。作为慢性进行性肾病组成部分观察到的透明管型不应单独诊断。管型的细节，例如在肾脏内的位置（如外髓内带与外带交界处，即α2u-球蛋白肾病相关管型的典型位置），应在病理学描述中讨论。相关链接：肾脏-肾小管-坏死
图谱
英文原文
展开 NTP 官方英文描述与建议
Comment：
Intratubular casts may have various compositions with different morphologic and staining characteristics. Both hyaline and granular casts may be observed in a number of renal diseases. Commonly observed casts are hyaline (eosinophilic, homogeneous proteinaceous) casts associated with increased glomerular permeability such as with chronic progressive nephropathy ( Figure 1 ) and granular (necrotic cellular debris) casts indicative of previous tubule cell necrosis associated with chemicals that induce α2u-globulin nephropathy ( Figure 2 and Figure 3 ).
Recommendation：
Tubule casts should be diagnosed according to their morphologic appearance (granular, hyaline, etc.) and given a severity grade. Hyaline casts observed as a component of chronic progressive nephropathy should not be diagnosed separately. Details of the casts, such as location within the kidney (e.g., the junction of the inner and outer stripes of the outer medulla, the typical location of casts associated with α2u-globulin nephropathy) should be discussed in the pathology narrative. Related Links: Kidney - Renal Tubule - Necrosis
来源与引用
原始条目：https://ntp.niehs.nih.gov/atlas/nnl/urinary-system/kidney/RenalTubule-Cast
图谱总目录：NTP Nonneoplastic Lesion Atlas。 内容属美国联邦政府作品（公有领域），可引用；引用时请标注来源。
建议引用格式：NTP Nonneoplastic Lesion Atlas. Renal Tubule Cast (kidney). LabSmart 中文版：
https://www.labsmart.cn/ntp/kidney-renal-tubule-cast.html
中文图谱总页（可展开对照全部 595 条）：https://www.labsmart.cn/ntp-atlas.html#kidney-renal-tubule-cast