肾小管嗜双色性空泡性增生Renal Tubule Hyperplasia Amphophilic Vacuolar · 肾脏 · 泌尿系统 · NTP ntp-0170
诊断要点：嗜酸性空泡性增生应诊断为“肾脏，肾小管 - 增生，嗜酸性空泡性”，并给出严重程度分级。
病变描述
嗜酸性空泡性（amphophilic-vacuolar，A-V）增生是一种小的增殖性病变，伴有程度不一的嗜酸性胞质染色及细胞内和/或细胞外空泡（Figure 1）。与非典型肾小管增生一样，在A-V增生中，增殖细胞被认为局限于单一肾小管范围内。如果细胞增殖超出单一肾小管的范围，则该病变被认为是肿瘤（腺瘤或癌）。A-V增生被推测为大鼠的一种家族性疾病，可能进展为肿瘤。
诊断与分级建议（NTP 共识）
嗜酸性空泡性增生应诊断为“肾脏，肾小管 - 增生，嗜酸性空泡性”，并给出严重程度分级。相关链接：肾脏 - 肾小管 - 非典型肾小管增生；肾脏 - 肾小管 - 增生，嗜酸性细胞性
图谱
英文原文
展开 NTP 官方英文描述与建议
Comment：
Amphophilic-vacuolar (A-V) hyperplasia is a small proliferative lesion associated with variable amphophilic cytoplasmic staining and intra- and/or extracellular vacuoles ( Figure 1 ). As with atypical tubule hyperplasia, in A-V hyperplasia the proliferating cells are considered to be within the confines of a single renal tubule. If the cells proliferate beyond the confines of a single tubule, the lesion is considered a neoplasm (adenoma or carcinoma). A-V hyperplasia has been postulated to be a familial condition in rats, which may progress to tumors.
Recommendation：
Amphophilic-vacuolar hyperplasia should be diagnosed as "Kidney, Renal tubule - Hyperplasia, Amphophilic-vacuolar" and given a severity grade. Related Links: Kidney - Renal Tubule - Atypical Tubule Hyperplasia Kidney - Renal Tubule - Hyperplasia, Oncocytic
来源与引用
图谱总目录：NTP Nonneoplastic Lesion Atlas。 内容属美国联邦政府作品（公有领域），可引用；引用时请标注来源。
建议引用格式：NTP Nonneoplastic Lesion Atlas. Renal Tubule Hyperplasia Amphophilic Vacuolar (kidney). LabSmart 中文版：
https://www.labsmart.cn/ntp/kidney-renal-tubule-hyperplasia-amphophilic-vacuolar.html
中文图谱总页（可展开对照全部 595 条）：https://www.labsmart.cn/ntp-atlas.html#kidney-renal-tubule-hyperplasia-amphophilic-vacuolar