肾小管再生Renal Tubule Regeneration · 肾脏 · 泌尿系统 · NTP ntp-0168
诊断要点：再生应当诊断并给出严重程度分级。伴随CPN相关再生的肾小管再生不应单独诊断，而应纳入CPN的诊断中。
病变描述
肾小管再生是对既往肾小管上皮变性和/或坏死的修复性反应。它是肾脏中最常见的受试物相关病变之一。再生的特征是一系列组织学改变，包括细胞质嗜碱性（cytoplasmic basophilia）、核增大（karyomegaly）以及受累肾小管节段核拥挤（nuclear crowding）（Figure 1、Figure 2）。与慢性进行性肾病（慢性（chronic） progressive nephropathy，CPN）不同，化学性损伤和再生一般不以基底膜增厚为特征。核分裂象（mitotic figures）多少不定。然而，化学性介导再生的判定可因CPN的存在而受到干扰，毒理病理学家可能难以区分。
诊断与分级建议（NTP 共识）
再生应当诊断并给出严重程度分级。伴随CPN相关再生的肾小管再生不应单独诊断，而应纳入CPN的诊断中。如果坏死显著，可同时诊断。增生与再生之间的区别可能存在问题，病理学家必须运用其判断来区分这些病变。相关链接：肾脏 - 肾小管 - 变性；肾脏 - 肾小管 - 坏死
图谱
英文原文
展开 NTP 官方英文描述与建议
Comment：
Renal tubule regeneration occurs as a reparative response to previous degeneration and/or necrosis of renal tubular epithelium. It is one of the most common test-article-related lesions observed in the kidney. Regeneration is characterized by a spectrum of histologic changes, including cytoplasmic basophilia, karyomegaly, and nuclear crowding along the affected tubule segment ( Figure 1 and Figure 2 ). In contrast to chronic progressive nephropathy (CPN), thickened basement membranes are generally not a feature with chemically induced injury and regeneration. Mitotic figures are variable. However, the determination of chemically mediated regeneration can be confounded by the presence of CPN and may be difficult for the toxicologic pathologist to distinguish.
Recommendation：
Regeneration should be diagnosed and given a severity grade. Tubule regeneration accompanying CPN-related regeneration should not be diagnosed separately but should be included in the diagnosis of CPN. If necrosis is significant, it may be diagnosed concurrently. The difference between hyperplasia and regeneration can be problematic, and the pathologist must use his or her judgment in differentiating these lesions. Related Links: Kidney - Renal Tubule - Degeneration Kidney - Renal Tubule - Necrosis
来源与引用
原始条目：https://ntp.niehs.nih.gov/atlas/nnl/urinary-system/kidney/RenalTubule-Regeneration
图谱总目录：NTP Nonneoplastic Lesion Atlas。 内容属美国联邦政府作品（公有领域），可引用；引用时请标注来源。
建议引用格式：NTP Nonneoplastic Lesion Atlas. Renal Tubule Regeneration (kidney). LabSmart 中文版：
https://www.labsmart.cn/ntp/kidney-renal-tubule-regeneration.html
中文图谱总页（可展开对照全部 595 条）：https://www.labsmart.cn/ntp-atlas.html#kidney-renal-tubule-regeneration