胆管囊肿Bile Duct Cyst · 肝 · 肝胆系统 · NTP ntp-0417
诊断要点：小的胆管囊肿偶尔可见于未处理的对照大鼠，但更常与处理相关。因此，只要存在就应记录并给予严重程度分级。
病变描述
单房和多房性胆管囊肿（biliary cysts）可在老年大鼠和小鼠中自发发生。它们可作为单个扩张的胆管结构、多个相邻的扩张胆管结构（Figure 1、Figure 2）或多房性囊肿（Figure 3）出现。胆管囊肿可伴随肝毒性，并可能与外周或基底部的胶原沉积有关（Figure 4）。它们通常由单层扁平或低立方上皮衬覆，几乎没有活跃增殖的证据。与胆管瘤（cholangiomas）不同，它们不压迫相邻的肝实质。
诊断与分级建议（NTP 共识）
小的胆管囊肿偶尔可见于未处理的对照大鼠，但更常与处理相关。因此，只要存在就应记录并给予严重程度分级。
图谱
英文原文
展开 NTP 官方英文描述与建议
Comment：
Single and multiloculated biliary cysts can occur spontaneously in older rats and mice. They can occur as single dilated biliary structures, multiple adjacent dilated biliary structures ( Figure 1 and Figure 2 ), or a multiloculated cyst ( Figure 3 ). Biliary cysts may accompany hepatic toxicity and may be associated with peripheral or sub-basilar collagen deposition ( Figure 4 ). They are typically lined by a single layer of flattened or low cuboidal epithelium ( Figure 4 ), with little evidence of active proliferation. In contrast to cholangiomas, they do not compress the adjacent hepatic parenchyma.
Recommendation：
Small biliary cysts may occasionally be seen in untreated rats but are more often associated with treatment. Consequently, they should be documented whenever present and given a severity grade.
来源与引用
原始条目：https://ntp.niehs.nih.gov/atlas/nnl/hepatobiliary-system/liver/BileDuct-Cyst
图谱总目录：NTP Nonneoplastic Lesion Atlas。 内容属美国联邦政府作品（公有领域），可引用；引用时请标注来源。
建议引用格式：NTP Nonneoplastic Lesion Atlas. Bile Duct Cyst (liver). LabSmart 中文版：
https://www.labsmart.cn/ntp/liver-bile-duct-cyst.html
中文图谱总页（可展开对照全部 595 条）：https://www.labsmart.cn/ntp-atlas.html#liver-bile-duct-cyst