卵圆细胞增生Oval Cell Hyperplasia · 肝 · 肝胆系统 · NTP ntp-0400
诊断要点：卵圆细胞增生只要存在即应作出诊断并给出严重程度分级，即使它是复杂肝脏病变组合的一部分。
病变描述
卵圆细胞增生（oval cell hyperplasia）（Figure 1）在对照动物中罕见。它通常始于汇管区周围区域或肝脏被膜下区域。增生的卵圆细胞呈纺锤状，初期以线性排列方式从汇管区向外延伸；它们可环绕肝小叶，严重病例中可形成增殖细胞的不规则实性巢。由于卵圆细胞增生主要发生于经肝毒性外源化学物处理的动物或感染病例中，因此通常伴有不同程度的肝细胞变性和坏死以及胆管增生。Figure 1评为2+（轻微（mild）），Figure 2、Figure 3、Figure 4评为4+（显著（marked））。
诊断与分级建议（NTP 共识）
卵圆细胞增生只要存在即应作出诊断并给出严重程度分级，即使它是复杂肝脏病变组合的一部分。卵圆细胞增生的模式和范围应连同伴随的肝脏病变一起在病理学描述中予以描述。
图谱
英文原文
展开 NTP 官方英文描述与建议
Comment：
Oval cell hyperplasia ( Figure 1 ) is rarely seen in control animals. It typically begins either in periportal areas or in subcapsular regions of the liver. The proliferating oval cells are spindloid and initially extend out from portal areas in a linear array; they may encircle hepatic lobules, and in severe cases they may form irregular solid nests of proliferating cells. Since oval cell hyperplasia occurs primarily in animals treated with hepatotoxic xenobiotics or in cases of infection, it is usually associated with varying degrees of hepatocyte degeneration and necrosis and bile duct hyperplasia. Figure 1 was graded as 2+ (mild), and Figure 2 , Figure 3 , and Figure 4 as 4+ (marked).
Recommendation：
Oval cell hyperplasia should be diagnosed and given a severity grade whenever present, even when part of a complex set of hepatic changes. The pattern and extent of oval cell hyperplasia should be described in the pathology narrative along with accompanying hepatic changes.
来源与引用
原始条目：https://ntp.niehs.nih.gov/atlas/nnl/hepatobiliary-system/liver/OvalCell-Hyperplasia
图谱总目录：NTP Nonneoplastic Lesion Atlas。 内容属美国联邦政府作品（公有领域），可引用；引用时请标注来源。
建议引用格式：NTP Nonneoplastic Lesion Atlas. Oval Cell Hyperplasia (liver). LabSmart 中文版：
https://www.labsmart.cn/ntp/liver-oval-cell-hyperplasia.html
中文图谱总页（可展开对照全部 595 条）：https://www.labsmart.cn/ntp-atlas.html#liver-oval-cell-hyperplasia