枯否细胞增生Kupffer Cell Hyperplasia · 肝 · 肝胆系统 · NTP ntp-0404
诊断要点：该组织学改变在未处理啮齿类动物中罕见，一旦出现即应作出诊断并分级。应在病理学描述中详细说明其形态学特征及组织分布。
病变描述
Kupffer细胞肥大与增生通常同时发生，可见于摄取外源性物质、受试物或代谢产物之后，其中任一情况均可能使细胞质着色为色素性。Kupffer细胞增生与肥大亦可发生于炎症状态下。增大的Kupffer细胞可形成片状或小结节状。
诊断与分级建议（NTP 共识）
该组织学改变在未处理啮齿类动物中罕见，一旦出现即应作出诊断并分级。应在病理学描述中详细说明其形态学特征及组织分布。由于肥大是这些细胞吞噬活性的结果，通常无需单独作出肥大的诊断。若色素沉着显著，可单独作出色素沉着的诊断，并附严重程度的定性分级。
图谱
英文原文
展开 NTP 官方英文描述与建议
Comment：
Kupffer cell hypertrophy and hyperplasia usually occur together and can be seen following uptake of foreign material, test agent, or metabolite, any of which may impart a pigment to the cytoplasm. Kupffer hyperplasia and hypertrophy may also occur in inflammatory conditions. The enlarged Kupffer cells may form sheets or small nodules.
Recommendation：
This tissue change is rare in untreated rodents and should be diagnosed and graded whenever present. A description of the morphologic features and tissue distribution should be detailed in the pathology narrative. Because hypertrophy is a consequence of the phagocytic activity of these cells, a separate diagnosis of hypertrophy is generally not necessary. If pigmentation is prominent, a separate diagnosis of pigmentation, along with a qualitative grading of severity, may be appropriate.
来源与引用
原始条目：https://ntp.niehs.nih.gov/atlas/nnl/hepatobiliary-system/liver/KupfferCell-Hyperplasia
图谱总目录：NTP Nonneoplastic Lesion Atlas。 内容属美国联邦政府作品（公有领域），可引用；引用时请标注来源。
建议引用格式：NTP Nonneoplastic Lesion Atlas. Kupffer Cell Hyperplasia (liver). LabSmart 中文版：
https://www.labsmart.cn/ntp/liver-kupffer-cell-hyperplasia.html
中文图谱总页（可展开对照全部 595 条）：https://www.labsmart.cn/ntp-atlas.html#liver-kupffer-cell-hyperplasia