肝细胞内红细胞Intrahepatocellular Erythrocytes · 肝 · 肝胆系统 · NTP ntp-0408
诊断要点：肝细胞内红细胞只要存在就应记录，病理描述中应包含该改变范围的描述。肝实质中任何相关的退行性或其他改变，若根据这些病变的严重程度有必要，应单独诊断；
病变描述
肝细胞内红细胞（intrahepatocellular erythrocytes）不常见，在老龄小鼠中可作为自发性改变出现。然而，在一些NTP研究中，该改变似乎因受试物处理而加重。在低倍镜下，它可能与血管扩张（angiectasis）相混淆；在高倍镜下，增大的肝细胞被大量红细胞填充并扩张。关于该改变由红细胞吞噬作用（erythrophagocytosis）或伸入运动（emperipolesis）所致的推测尚未经超微结构研究证实。
诊断与分级建议（NTP 共识）
肝细胞内红细胞只要存在就应记录，病理描述中应包含该改变范围的描述。肝实质中任何相关的退行性或其他改变，若根据这些病变的严重程度有必要，应单独诊断；否则，应在病理描述中提及。
图谱
英文原文
展开 NTP 官方英文描述与建议
Comment：
Intrahepatocellular erythrocytes are uncommon and may be seen as a spontaneous change in aging mice. However, in some NTP studies, this change appears to have been exacerbated by treatment. At low magnification, it may be confused with angiectasis; at higher magnification, enlarged hepatocytes are filled and expanded by numerous erythrocytes. Speculation that this change occurs by erythrophagocytosis or emperipolesis has not been confirmed by ultrastructural studies.
Recommendation：
Intrahepatocellular erythrocytes should be documented whenever present, and the pathology narrative should include a description of the extent of the change. Any associated degenerative or other changes in the hepatic parenchyma should be diagnosed separately if warranted by the severity of these lesions; otherwise, they should be mentioned in the pathology narrative.
来源与引用
原始条目：https://ntp.niehs.nih.gov/atlas/nnl/hepatobiliary-system/liver/IntrahepatocellularErythrocytes
图谱总目录：NTP Nonneoplastic Lesion Atlas。 内容属美国联邦政府作品（公有领域），可引用；引用时请标注来源。
建议引用格式：NTP Nonneoplastic Lesion Atlas. Intrahepatocellular Erythrocytes (liver). LabSmart 中文版：
https://www.labsmart.cn/ntp/liver-intrahepatocellular-erythrocytes.html
中文图谱总页（可展开对照全部 595 条）：https://www.labsmart.cn/ntp-atlas.html#liver-intrahepatocellular-erythrocytes