腺体囊肿Glands Cyst · 肺 · 呼吸系统 · NTP ntp-0115
诊断要点：肺，腺体 - 囊肿：当与处理相关时应作出诊断，但不进行分级。
病变描述
衬覆支气管的黏膜下腺囊性扩张（Figure 1、Figure 2、Figure 3、Figure 4）在啮齿类动物毒性研究中偶见。可累及单个（Figure 1、Figure 2）或多个（Figure 3、Figure 4）腺体。受累腺体通常含有细胞碎片、腺体分泌物和炎性细胞。衬覆上皮细胞通常变薄，可呈低立方状或扁平状。黏膜下腺囊肿可能由分泌管阻塞所致，其原因可能是覆盖其上的黏膜上皮发生鳞状化生，导致分泌物潴留和腺体扩张。通常，腺体囊肿为偶然发现，不伴有其他气道病变，且与衰老有关。尚未见有化学物质诱导支气管和细支气管腺体发生囊肿的报道。
诊断与分级建议（NTP 共识）
肺，腺体 - 囊肿：当与处理相关时应作出诊断，但不进行分级。
图谱
英文原文
展开 NTP 官方英文描述与建议
Comment：
Cystically dilated submucosal glands lining the bronchi ( Figure 1 , Figure 2 , Figure 3 , and Figure 4 ) are occasionally seen in rodent toxicity studies. Single ( Figure 1 and Figure 2 ) or multiple ( Figure 3 and Figure 4 ) glands may be affected. The affected glands typically contain cellular debris, glandular secretions, and inflammatory cells. The lining epithelial cells are typically attenuated and may be low cuboidal or flattened. Submucosal gland cysts may be caused by obstruction of the secretory ducts, possibly due to squamous metaplasia of the overlying mucosal epithelium that results in trapped secretions and glandular dilatation. Typically, the glandular cyst is an incidental finding with no other airway lesions and is related to aging. Chemical agents inducing cysts in the bronchial and bronchiolar glands have not been reported.
Recommendation：
Lung, Glands - Cyst should be diagnosed when treatment related but not graded.
来源与引用
原始条目：https://ntp.niehs.nih.gov/atlas/nnl/respiratory-system/lung/Glands-Cyst
图谱总目录：NTP Nonneoplastic Lesion Atlas。 内容属美国联邦政府作品（公有领域），可引用；引用时请标注来源。
建议引用格式：NTP Nonneoplastic Lesion Atlas. Glands Cyst (lung). LabSmart 中文版：
https://www.labsmart.cn/ntp/lung-glands-cyst.html
中文图谱总页（可展开对照全部 595 条）：https://www.labsmart.cn/ntp-atlas.html#lung-glands-cyst