肝细胞化生Metaplasia Hepatocyte · 胰岛 · 内分泌系统 · NTP ntp-0093
诊断要点：由于此病变与外源性物质暴露相关，故只要存在即应诊断并分级。分级应基于受累胰岛的数量及存在的肝细胞数量。
病变描述
胰岛细胞肝细胞化生（hepatocyte metaplasia）的特征是偶见胰岛内出现肝细胞，通常位于胰岛周边。虽然在大鼠中这可能是偶然发现，但肝细胞化生可由过氧化物酶体增殖物（peroxisome proliferators）、甲基缺乏饮食诱导，也可通过实验性铜给予/撤除诱导。在外源性物质（xenobiotics）诱导后15周内可出现化生的肝细胞。
诊断与分级建议（NTP 共识）
由于此病变与外源性物质暴露相关，故只要存在即应诊断并分级。分级应基于受累胰岛的数量及存在的肝细胞数量。
图谱
英文原文
展开 NTP 官方英文描述与建议
Comment：
Hepatocyte metaplasia of pancreatic islet cells is characterized by the presence of hepatocytes in an occasional islet, usually at the islet periphery. While it may be an incidental finding in rats, hepatocyte metaplasia can be induced by peroxisome proliferators, by methyl-deficient diets, and experimentally by copper administration/withdrawal. Metaplastic hepatocytes can occur within 15 weeks following induction by xenobiotics.
Recommendation：
Because this change has been associated with exposure to xenobiotics, it should be diagnosed whenever present and graded. Grading should be based on number of islets affected and number of hepatocytes present.
来源与引用
原始条目：https://ntp.niehs.nih.gov/atlas/nnl/endocrine-system/pancreatic-islets/MetaplasiaHepatocyte
图谱总目录：NTP Nonneoplastic Lesion Atlas。 内容属美国联邦政府作品（公有领域），可引用；引用时请标注来源。
建议引用格式：NTP Nonneoplastic Lesion Atlas. Metaplasia Hepatocyte (pancreatic-islets). LabSmart 中文版：
https://www.labsmart.cn/ntp/pancreatic-islets-metaplasia-hepatocyte.html
中文图谱总页（可展开对照全部 595 条）：https://www.labsmart.cn/ntp-atlas.html#pancreatic-islets-metaplasia-hepatocyte