纤维化Fibrosis · 唾液腺 · 消化系统 · NTP ntp-0242
诊断要点：凡纤维化作为唯一病变存在时，均应诊断并分级。然而，除非是病变的终末期，纤维化很少在没有同时存在的组织损伤或炎症的情况下出现。
病变描述
纤维化可见于唾液腺内及周围（Figure 1、Figure 2），且常取代腺体组织。它可与严重炎症和坏死同时出现。在某些慢性病例中，炎症和坏死已消退，纤维化表现为基本无细胞的嗜酸性组织。此类情况下，受累腺体或小叶可能较小，且腺泡可能发生萎缩。
诊断与分级建议（NTP 共识）
凡纤维化作为唯一病变存在时，均应诊断并分级。然而，除非是病变的终末期，纤维化很少在没有同时存在的组织损伤或炎症的情况下出现。凡纤维化是退行性、坏死性或炎症性病变的重要组成成分时，均应诊断并分级。被认为继发于纤维化的腺体组织萎缩不应单独诊断，除非它是病变的显著组成成分。继发性病变应在病理学描述中记述。
图谱
英文原文
展开 NTP 官方英文描述与建议
Comment：
Fibrosis can be found in and around the salivary glands ( Figure 1 and Figure 2 ) and often replaces glandular tissue. It may be seen concurrently with severe inflammation and necrosis. In some chronic cases, the inflammation and necrosis have resolved and the fibrosis appears as largely acellular, eosinophilic tissue. In such cases, the affected gland or lobule may be small, and there may be atrophy of the glandular acini.
Recommendation：
Whenever present as the sole lesion, fibrosis should be diagnosed and graded. However, unless it is the end stage of a lesion, fibrosis is rarely seen without concurrent tissue damage or inflammation. Whenever it is a significant component of a degenerative, necrotic, or inflammatory lesion, fibrosis should be diagnosed and graded. Atrophy of glandular tissue that is considered secondary to fibrosis should not be diagnosed separately unless it is a prominent component of the lesion. Secondary lesions should be described in the pathology narrative.
来源与引用
原始条目：https://ntp.niehs.nih.gov/atlas/nnl/alimentary-system/salivary-gland/Fibrosis
图谱总目录：NTP Nonneoplastic Lesion Atlas。 内容属美国联邦政府作品（公有领域），可引用；引用时请标注来源。
建议引用格式：NTP Nonneoplastic Lesion Atlas. Fibrosis (salivary-gland). LabSmart 中文版：
https://www.labsmart.cn/ntp/salivary-gland-fibrosis.html
中文图谱总页（可展开对照全部 595 条）：https://www.labsmart.cn/ntp-atlas.html#salivary-gland-fibrosis