化生Metaplasia · 膀胱 · 泌尿系统 · NTP ntp-0187
诊断要点:尿路上皮化生,特别是化生的类型,当它成为病变的主要部分时,例如与炎症或增生相关时,应当诊断并给出严重程度分级。
病变描述
尿路上皮化生(metaplasia)反映了尿路上皮在多种条件下发生化生性改变的能力。鳞状化生(squamous metaplasia),伴或不伴角化,是最常见的变异型(Figure 1、Figure 2、Figure 3)。黏液性、腺性或混合性化生性病变较少见(Figure 4)。
诊断与分级建议(NTP 共识)
尿路上皮化生,特别是化生的类型,当它成为病变的主要部分时,例如与炎症或增生相关时,应当诊断并给出严重程度分级。当小病变或局灶性(focal)病变是原发性病变(如慢性炎症和/或增生)的一部分时,不应单独诊断。
图谱


英文原文
展开 NTP 官方英文描述与建议
Comment:
Metaplasia of the urothelium reflects the potential of the urothelium to undergo a metaplastic change under a variety of conditions. Squamous metaplasia, with or without keratinization, is the most common variant observed ( Figure 1 , Figure 2 , and Figure 3 ). Mucinous, glandular, or mixtures of metaplastic lesions are less commonly observed ( Figure 4 ).
Recommendation:
Urothelial metaplasia and, in particular, the type of metaplasia should be diagnosed and given a severity grade when it becomes a major part of a lesion, for instance, in association with inflammation or hyperplasia. Small or focal lesions, when part of a primary lesion such as chronic inflammation and/or hyperplasia, should not be diagnosed separately.
来源与引用
原始条目:https://ntp.niehs.nih.gov/atlas/nnl/urinary-system/urinary-bladder/Metaplasia
图谱总目录:NTP Nonneoplastic Lesion Atlas。 内容属美国联邦政府作品(公有领域),可引用;引用时请标注来源。
建议引用格式:NTP Nonneoplastic Lesion Atlas. Metaplasia (urinary-bladder). LabSmart 中文版:
https://www.labsmart.cn/ntp/urinary-bladder-metaplasia.html
中文图谱总页(可展开对照全部 595 条):https://www.labsmart.cn/ntp-atlas.html#urinary-bladder-metaplasia