坏死Necrosis · 膀胱 · 泌尿系统 · NTP ntp-0188
诊断要点：尿路上皮坏死应予以诊断并给出严重程度分级。病理学家应运用其判断来决定与坏死相关的继发性病变是否足够显著，以 warrant 单独诊断。
病变描述
尿路上皮坏死可能由细胞毒性所致，包括直接给予化学物质或晶体和结石引起的刺激，并可能与溃疡和炎症相关。坏死通过细胞嗜酸性变和碎裂，以及核固缩和核碎裂来识别（Figure 1）。变性可能先于坏死发生，但单纯变性很少被诊断。既往坏死的区域可发生再生并愈合，或导致尿路上皮增生。
诊断与分级建议（NTP 共识）
尿路上皮坏死应予以诊断并给出严重程度分级。病理学家应运用其判断来决定与坏死相关的继发性病变是否足够显著，以 warrant 单独诊断。相关链接：Urinary Bladder - Ulcer
图谱
英文原文
展开 NTP 官方英文描述与建议
Comment：
Necrosis of the urothelium may be due to cytotoxicity, including direct chemical administration or irritation from crystals and calculi and may be associated with ulceration and inflammation. Necrosis is recognized by cellular eosinophilia and fragmentation, as well as nuclear pyknosis and karyorrhexis ( Figure 1 ). Degeneration may precede necrosis, but degeneration by itself is infrequently diagnosed. Areas of previous necrosis can undergo regeneration and heal or result in urothelial hyperplasia.
Recommendation：
Necrosis of the urothelium should be diagnosed and given a severity grade. The pathologist should use his or her judgment in deciding whether or not secondary lesions associated with necrosis are prominent enough to warrant a separate diagnosis. Related Links: Urinary Bladder - Ulcer
来源与引用
原始条目：https://ntp.niehs.nih.gov/atlas/nnl/urinary-system/urinary-bladder/Necrosis
图谱总目录：NTP Nonneoplastic Lesion Atlas。 内容属美国联邦政府作品（公有领域），可引用；引用时请标注来源。
建议引用格式：NTP Nonneoplastic Lesion Atlas. Necrosis (urinary-bladder). LabSmart 中文版：
https://www.labsmart.cn/ntp/urinary-bladder-necrosis.html
中文图谱总页（可展开对照全部 595 条）：https://www.labsmart.cn/ntp-atlas.html#urinary-bladder-necrosis