尿路上皮细胞质颗粒Urothelium Cytoplasmic Granules · 膀胱 · 泌尿系统 · NTP ntp-0190
诊断要点:细胞质颗粒应予以诊断并给出严重程度分级。如果与处理相关,则应在叙述性报告中描述颗粒的任何独特特征。
病变描述
在尿路上皮最表层的上皮“伞”细胞内可能观察到细胞质颗粒。它们很少出现在中间细胞或基底细胞中,通常呈深嗜酸性。这些颗粒可能代表多种已报道的成分,如降解产物、化学物质/代谢物或线粒体。细胞质颗粒的存在通常不引起细胞反应,且未与癌前病变或肿瘤形成相关联。
诊断与分级建议(NTP 共识)
细胞质颗粒应予以诊断并给出严重程度分级。如果与处理相关,则应在叙述性报告中描述颗粒的任何独特特征。
图谱


英文原文
展开 NTP 官方英文描述与建议
Comment:
Cytoplasmic granules may be observed within the most superficial epithelial “umbrella” cells of the urothelium. They rarely occur in the intermediate or basal cells and typically are deeply eosinophilic. The granules may represent a number of reported constituents, such as degradation products, chemicals/metabolites, or mitochondria. The presence of cytoplasmic granules usually elicits no cell response and has not been associated with either preneoplasia or neoplasia.
Recommendation:
Cytoplasmic granules should be diagnosed and given a severity grade. If treatment related, any unique characteristics of the granules should be described in the narrative report.
来源与引用
原始条目:https://ntp.niehs.nih.gov/atlas/nnl/urinary-system/urinary-bladder/Urothelium-CytoplasmicGranules
图谱总目录:NTP Nonneoplastic Lesion Atlas。 内容属美国联邦政府作品(公有领域),可引用;引用时请标注来源。
建议引用格式:NTP Nonneoplastic Lesion Atlas. Urothelium Cytoplasmic Granules (urinary-bladder). LabSmart 中文版:
https://www.labsmart.cn/ntp/urinary-bladder-urothelium-cytoplasmic-granules.html
中文图谱总页(可展开对照全部 595 条):https://www.labsmart.cn/ntp-atlas.html#urinary-bladder-urothelium-cytoplasmic-granules