角膜纤维化Cornea Fibrosis · 眼 · 特殊感觉系统 · NTP ntp-0352
诊断要点：不伴有炎症或仅伴有极轻微（minimal）炎症的纤维化，应当诊断并赋予严重程度分级。
病变描述
角膜基质纤维化（corneal stromal fibrosis）（Figure 1）的特征是正常的规则胶原板层结构被粗糙、不规则的胶原纤维束（瘢痕组织）所取代。这些变化导致角膜透明度丧失。新替代的胶原由常驻的基质角膜细胞（stromal keratocytes）产生，这些细胞对损伤作出反应，发生表型转变成为成纤维细胞（fibroblasts）和肌成纤维细胞（myofibroblasts），同时也由骨髓来源的细胞产生，这些细胞响应损伤迁移至角膜。角膜纤维化是一种反应性改变，由多种原因引起，通常与新生血管形成和/或炎症同时发生（Figure 1）。
诊断与分级建议（NTP 共识）
不伴有炎症或仅伴有极轻微（minimal）炎症的纤维化，应当诊断并赋予严重程度分级。当角膜纤维化被认为是继发于炎症时，不应单独诊断，除非其严重程度足以支持单独诊断，但应在病理学叙述中予以描述。
图谱
英文原文
展开 NTP 官方英文描述与建议
Comment：
Fibrosis of the corneal stroma ( Figure 1 ) is characterized by replacement of the normal orderly collagen lamellar architecture by coarse, irregular bundles of collagenous fibers (scar tissue). These changes result in loss of corneal transparency. The new replacement collagen is produced by the resident stromal keratocytes, which respond to injury by undergoing phenotypic transition into fibroblasts and myofibroblasts, as well as by bone-marrow-derived cells that migrate to the cornea in response to injury. Corneal fibrosis is a reactive change resulting from various causes that generally occur in conjunction with neovascularization and/or inflammation ( Figure 1 ).
Recommendation：
Fibrosis that occurs without, or with only minimal, concurrent inflammation, it should be diagnosed and assigned a severity grade. When corneal fibrosis is considered secondary to inflammation, it should not be diagnosed separately unless warranted by its severity, though it should be described in the pathology narrative.
来源与引用
原始条目：https://ntp.niehs.nih.gov/atlas/nnl/special-senses-system/eye/Cornea-Fibrosis
图谱总目录：NTP Nonneoplastic Lesion Atlas。 内容属美国联邦政府作品（公有领域），可引用；引用时请标注来源。
建议引用格式：NTP Nonneoplastic Lesion Atlas. Cornea Fibrosis (eye). LabSmart 中文版：
https://www.labsmart.cn/ntp/eye-cornea-fibrosis.html
中文图谱总页（可展开对照全部 595 条）：https://www.labsmart.cn/ntp-atlas.html#eye-cornea-fibrosis