角膜杯状细胞化生Cornea Metaplasia Goblet Cell · 眼 · 特殊感觉系统 · NTP ntp-0348
诊断要点:角膜杯状细胞化生一经出现即应诊断并赋予严重程度分级。该病变通常为反应性,继发于其他病理过程,但其不寻常的性质决定了必须对其进行诊断。
病变描述
杯状细胞(goblet cell)通常存在于结膜上皮中,但当其出现在角膜上皮时,即被视为一种化生性改变(Figure 1、Figure 2)。这种所谓的角膜上皮结膜化被认为是继发性反应性改变,常与各种原因所致的角膜新生血管形成和/或炎症相关。
诊断与分级建议(NTP 共识)
角膜杯状细胞化生一经出现即应诊断并赋予严重程度分级。该病变通常为反应性,继发于其他病理过程,但其不寻常的性质决定了必须对其进行诊断。当存在炎症时,应另行诊断。
图谱


英文原文
展开 NTP 官方英文描述与建议
Comment:
Goblet cells are normally present in the conjunctival epithelium, but when they appear in the corneal epithelium, it is recognized as a metaplasitic change ( Figure 1 and Figure 2 ). Such so-called conjunctivalization of the corneal epithelium is considered a secondary reactive change, often associated with corneal neovascularization and/or inflammation from various causes.
Recommendation:
Corneal goblet cell metaplasia should be diagnosed and assigned a severity grade whenever present. It is generally reactive and secondary to other pathologic processes, but it’s unusual nature necessitates its diagnosis. When present, inflammation should be diagnosed separately.
来源与引用
原始条目:https://ntp.niehs.nih.gov/atlas/nnl/special-senses-system/eye/Cornea-MetaplasiaGobletCell
图谱总目录:NTP Nonneoplastic Lesion Atlas。 内容属美国联邦政府作品(公有领域),可引用;引用时请标注来源。
建议引用格式:NTP Nonneoplastic Lesion Atlas. Cornea Metaplasia Goblet Cell (eye). LabSmart 中文版:
https://www.labsmart.cn/ntp/eye-cornea-metaplasia-goblet-cell.html
中文图谱总页(可展开对照全部 595 条):https://www.labsmart.cn/ntp-atlas.html#eye-cornea-metaplasia-goblet-cell