角膜坏死Cornea Necrosis · 眼 · 特殊感觉系统 · NTP ntp-0346
诊断要点：角膜坏死一经出现即应诊断，并赋予严重程度分级。角膜坏死的亚部位（上皮、内皮、基质）可在病理学描述中说明。
病变描述
角膜上皮细胞坏死（necrosis of corneal epithelial cells）的特征是皱缩、嗜酸性增多的坏死细胞（提示为单细胞坏死）散布于上皮层中（Figure 1、Figure 2）。这些细胞还可能表现为与相邻细胞失去附着。上皮坏死可进展为糜烂和溃疡。其他角膜细胞类型（例如角膜内皮细胞和基质角膜细胞）也可发生坏死。角膜上皮坏死可能伴有上皮增生或炎症。
诊断与分级建议（NTP 共识）
角膜坏死一经出现即应诊断，并赋予严重程度分级。角膜坏死的亚部位（上皮、内皮、基质）可在病理学描述中说明。相关病变（例如炎症）应单独诊断。
图谱
英文原文
展开 NTP 官方英文描述与建议
Comment：
Necrosis of corneal epithelial cells is characterized by shrunken, hypereosinophilic necrotic cells (suggestive of single-cell necrosis) are scattered through the epithelium ( Figure 1 and Figure 2 ). The cells may also appear to have lost their attachments to adjacent cells. Epithelial necrosis can progress to erosion and ulceration. Other corneal cell types (e.g., corneal endothelial cells and stromal keratocytes) can also undergo necrosis. Corneal epithelial necrosis may be accompanied by epithelial hyperplasia or inflammation.
Recommendation：
Corneal necrosis should be diagnosed whenever present and assigned a severity grade. The subtopography of corneal necrosis (epithelium, endothelium, stroma) can be described in the pathology narrative. Associated lesions (e.g., inflammation) should be diagnosed separately.
来源与引用
原始条目：https://ntp.niehs.nih.gov/atlas/nnl/special-senses-system/eye/Cornea-Necrosis
图谱总目录：NTP Nonneoplastic Lesion Atlas。 内容属美国联邦政府作品（公有领域），可引用；引用时请标注来源。
建议引用格式：NTP Nonneoplastic Lesion Atlas. Cornea Necrosis (eye). LabSmart 中文版：
https://www.labsmart.cn/ntp/eye-cornea-necrosis.html
中文图谱总页（可展开对照全部 595 条）：https://www.labsmart.cn/ntp-atlas.html#eye-cornea-necrosis