滤泡细胞肥大Follicular Cell Hypertrophy · 甲状腺 · 内分泌系统 · NTP ntp-0066

Comment：
In follicular cell hypertrophy, thyroid follicles may be lined by cuboidal to columnar epithelium with central follicles tightly packed and smaller than normal ( Figure 1 and Figure 2 ). Focal hyperplasia of follicular epithelium may sometimes accompany follicular hypertrophy ( Figure 1 , arrows). Bilateral hypertrophy is expected as a systemic response to increased pituitary secretion of thyroid-stimulating hormone. Hypertrophic follicular epithelium may contain pale eosinophilic cytoplasm and small clear vacuoles ( Figure 3 ). In more chronic follicular epithelial hypertrophy, all follicles may be smaller than normal, with secretory depletion or abnormal secretion and exfoliated epithelium ( Figure 4 ). The presence of thyroid follicular cell hypertrophy may be secondary to hepatocellular microsomal enzyme induction, and hepatocellular hypertrophy is often seen concomitantly in rats with thyroid gland follicular cell hypertrophy.

Recommendation：
Thyroid follicular cell hypertrophy should be diagnosed and graded when present. The pathology narrative can describe the nature of the hypertrophic follicular epithelium and whether bilateral, accompanied by follicular hyperplasia, or associated with alterations in colloid.