色素Pigment · 膀胱 · 泌尿系统 · NTP ntp-0198
诊断要点:色素沉积应当诊断并给出严重程度分级。除用于含铁血黄素的普鲁士蓝(Prussian blue)染色外,即使使用一系列特殊染色,在组织学切片中明确鉴定色素类型通常也很困难。
病变描述
啮齿类动物膀胱中色素沉积罕见报道。最常见的色素是含铁血黄素(hemosiderin)(Figure 1)。给予染料化合物后可见尿路上皮色素沉着。
诊断与分级建议(NTP 共识)
色素沉积应当诊断并给出严重程度分级。除用于含铁血黄素的普鲁士蓝(Prussian blue)染色外,即使使用一系列特殊染色,在组织学切片中明确鉴定色素类型通常也很困难。因此,推荐诊断为“色素沉积”(而非诊断色素类型,例如含铁血黄素或脂褐素)更为恰当。病理学描述应描述色素的形态学特征。
图谱

英文原文
展开 NTP 官方英文描述与建议
Comment:
Pigment is rarely reported in urinary bladders of rodents. The most common pigment is hemosiderin ( Figure 1 ). Pigmentation of urothelium has been observed with administered dye compounds.
Recommendation:
Pigment should be diagnosed and given a severity grade. With the exception of Prussian blue staining for hemosiderin, definitive pigment identification is often difficult in histologic sections, even with a battery of special stains. Therefore, it is recommended that a diagnosis of “pigment” (as opposed to diagnosing the type of pigment, e.g., hemosiderin or lipofuscin) is more appropriate. The pathology narrative should describe the morphologic features of the pigment.
来源与引用
原始条目:https://ntp.niehs.nih.gov/atlas/nnl/urinary-system/urinary-bladder/Pigment
图谱总目录:NTP Nonneoplastic Lesion Atlas。 内容属美国联邦政府作品(公有领域),可引用;引用时请标注来源。
建议引用格式:NTP Nonneoplastic Lesion Atlas. Pigment (urinary-bladder). LabSmart 中文版:
https://www.labsmart.cn/ntp/urinary-bladder-pigment.html
中文图谱总页(可展开对照全部 595 条):https://www.labsmart.cn/ntp-atlas.html#urinary-bladder-pigment