嗜酸性物质Eosinophilic Material · 鼻 · 呼吸系统 · NTP ntp-0136
诊断要点：在缺乏特殊染色或免疫组化染色证明该物质为淀粉样物质的情况下，此变化应诊断为“鼻——嗜酸性物质”。
病变描述
鼻——嗜酸性物质（eosinophilic material）是鼻腔黏膜下可能蓄积的任何无定形、嗜酸性物质的总称，包括淀粉样物质（amyloid）。嗜酸性物质蓄积的常见部位是犁鼻器（vomeronasal organ）背侧的腹侧鼻中隔（Figure 1）。该物质此前因其形态学外观而被认为是淀粉样物质，但Doi等人（2007、2009、2010）近期的数篇论文表明，该物质在许多情况下并非淀粉样物质，而是由胶原和复杂碳水化合物组成，可能由鼻腔腺上皮细胞产生，且刚果红（Congo red）染色阴性。然而，在某些情况下，淀粉样物质沉积相对常见，并可在鼻腔内发现。
诊断与分级建议（NTP 共识）
在缺乏特殊染色或免疫组化染色证明该物质为淀粉样物质的情况下，此变化应诊断为“鼻——嗜酸性物质”。由于这是一种随年龄增长而增加的自发性变化，且迄今未知其会随受试物处理而增加，因此除非有明确证据表明存在处理相关效应，否则不应诊断该病变。此变化无需分级，除非分级有助于阐明处理效应。
图谱
英文原文
展开 NTP 官方英文描述与建议
Comment：
Nose - Eosinophilic material is a general term for any amorphous, eosinophilic material that may accumulate in the submucosa in the nasal cavity, including amyloid. A common site for accumulation of eosinophilic material is the ventral nasal septum just dorsal to the vomeronasal organ ( Figure 1 ). This material was previously thought to be amyloid due to its morphologic appearance, but several recent publications by Doi et al. (2007, 2009, 2010) have shown that this material is not, in many cases, amyloid but consists of collagen and complex carbohydrates that may be produced by nasal gland epithelial cells that is Congo red negative. In some cases, however, amyloid deposition is relatively common and can be found in the nasal cavity.
Recommendation：
In the absence of special or immunohistochemical stains showing that the material is amyloid, this change should be diagnosed as "Nose - Eosinophilic material." Since this is a spontaneous change that increases with age and, to date, is not known to be increased with treatment, this lesion should not be diagnosed unless there is clear evidence of a treatment-related effect. This change need not be graded unless grading would clarify a treatment effect.
来源与引用
原始条目：https://ntp.niehs.nih.gov/atlas/nnl/respiratory-system/nose/EosinophilicMaterial
图谱总目录：NTP Nonneoplastic Lesion Atlas。 内容属美国联邦政府作品（公有领域），可引用；引用时请标注来源。
建议引用格式：NTP Nonneoplastic Lesion Atlas. Eosinophilic Material (nose). LabSmart 中文版：
https://www.labsmart.cn/ntp/nose-eosinophilic-material.html
中文图谱总页（可展开对照全部 595 条）：https://www.labsmart.cn/ntp-atlas.html#nose-eosinophilic-material