嗅上皮萎缩Olfactory Epithelium Atrophy · 鼻 · 呼吸系统 · NTP ntp-0135
诊断要点：当病变与其他嗅上皮变化（如变性、坏死或呼吸上皮化生）明显分开时，应诊断嗅上皮萎缩。
病变描述
嗅上皮萎缩（olfactory epithelial atrophy）是指上皮细胞丢失，导致上皮变薄、细胞数量减少（Figure 1、Figure 2、Figure 3、Figure 4）。上皮表面可能覆盖立方至柱状无纤毛上皮。它通常是鼻部一系列变化的一部分，这些变化包括炎症、变性或坏死，以及呼吸上皮或鳞状上皮化生。事实上，嗅上皮萎缩往往是嗅上皮变性或坏死的最终结果。下方的鼻甲骨也可能发生萎缩。
诊断与分级建议（NTP 共识）
当病变与其他嗅上皮变化（如变性、坏死或呼吸上皮化生）明显分开时，应诊断嗅上皮萎缩。炎症、嗅神经萎缩和鼻甲萎缩可能伴随上皮变化出现，应分别诊断（见 Nose - Inflammation；Nose - Nerve - Atrophy；和 Nose - Turbinate - Atrophy）。相关链接：Nose - Inflammation Nose - Nerve - Atrophy Nose - Turbinate - Atrophy
图谱
英文原文
展开 NTP 官方英文描述与建议
Comment：
Olfactory epithelial atrophy is a loss of cells from the epithelium, resulting in a thinner and less cellular epithelium ( Figure 1 , Figure 2 , Figure 3 , and Figure 4 ). The epithelial surface may be covered with cuboidal to columnar nonciliated epithelium. It is often part of a spectrum of changes in the nose that includes inflammation, degeneration or necrosis, and respiratory or squamous metaplasia. In fact, olfactory epithelial atrophy is often the end result of degeneration or necrosis of the olfactory epithelium. The underlying turbinate bone may also be atrophic.
Recommendation：
Olfactory epithelial atrophy should be diagnosed when a lesion is clearly separate from other olfactory epithelial changes such as degeneration, necrosis, or respiratory epithelial metaplasia. Inflammation, olfactory nerve atrophy, and turbinate atrophy may accompany the epithelial changes and should be diagnosed separately (see Nose - Inflammation ; Nose - Nerve - Atrophy ; and Nose - Turbinate - Atrophy ). Related Links: Nose - Inflammation Nose - Nerve - Atrophy Nose - Turbinate - Atrophy
来源与引用
原始条目：https://ntp.niehs.nih.gov/atlas/nnl/respiratory-system/nose/OlfactoryEpithelium-Atrophy
图谱总目录：NTP Nonneoplastic Lesion Atlas。 内容属美国联邦政府作品（公有领域），可引用；引用时请标注来源。
建议引用格式：NTP Nonneoplastic Lesion Atlas. Olfactory Epithelium Atrophy (nose). LabSmart 中文版：
https://www.labsmart.cn/ntp/nose-olfactory-epithelium-atrophy.html
中文图谱总页（可展开对照全部 595 条）：https://www.labsmart.cn/ntp-atlas.html#nose-olfactory-epithelium-atrophy